Senior Scientist, Clinical Manufacturing

Company: Pfizer
Location: Chapel Hill
Posted on: May 3, 2021

Job Description:

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of Pfizer's Worldwide Research & Development in a group that uses a multidisciplinary approach to identify and validate targets in cancer cell cycle and tumor microenvironment with the objective to develop the next generation of oncology therapeutics. You will help the team achieve their objective through your substantial experience in protein display technologies, especially phage and mammalian display along with extensive hands-on in mammalian cell culture and protein biochemistry.

You will be instrumental in setting up and optimizing a novel platform for antibody discovery. You will also balance library screening and target validation responsibilities. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be recognized as a technical expert and a scientific contributor. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Regularly contribute and influence at the project team level.
• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, and continuous learning and improvement.
• Establish and execute molecular and cell-based assays across a wide variety of technical platforms to assess target modulation and its impact on immune function and

tumor-susceptibility, cell viability and cell cycle disruption, transcription and downstream signal transduction.

• Responsible for biosensor assay development to evaluate protein-protein interactions including antibodies, drug targets from Human and surrogate species, soluble receptors, and receptor ligands to support the development and characterization of biotherapeutic drug incumbents.
• Present research results and discuss methods at weekly and/or monthly group meetings.

Qualifications

Must-Have

• Bachelor's Degree
• 9+ years of experience
• Strong documented experience in protein biochemistry, protein purification, protein modification using enzymatic and chemical methods, and biophysical characterization
• Experience with antibody engineering in developing immunotherapeutics
• Experience and knowledge in operation of modern mass spectrometry platforms and associated data analysis packages
• Expert level knowledge of assay development methodologies for binding and functional activity
• Ability to deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment
• Excellent written and oral communication skills

Nice-to-Have

• Master's degree with 7+ years of experience or PhD with 0-3 years of relevant experience
• Background in immuno-oncology and/or experience in target identification/validation
• Experience with methods for successful purification of integral membrane proteins
• Computational skills using Biacore, Octet, Microsoft Excel, and other applications designed to evaluate, process, and manage biosensor data

Other Job Details:

• Last Date to Apply for Job: May 28, 2021
• Eligible for Employee Referral Bonus: YES

#LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Keywords: Pfizer, Chapel Hill , Senior Scientist, Clinical Manufacturing, Other , Chapel Hill, North Carolina